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Efficient immunization of rhesus macaques with an HCV candidate vaccine by heterologous priming-boosting with novel adenoviral vectors based on different serotypes

机译：通过基于不同血清型的新型腺病毒载体进行异源引发加强，用HCV候选疫苗对恒河猴进行有效免疫

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Efficient vaccination against viral agents requires a strong T-cell-mediated immune response to clear viral-infected cells. Optimal vaccination can be achieved by administration of recombinant viral vectors encoding phatogen antigens. Adenoviral vectors have attracted considerable attention as potential viral vectors for genetic vaccination owing to their favorable safety profile and potent transduction efficiency following intramuscular injection. However, the neutralizing antibody response against adenoviral capsid proteins following adenoviral vectors injection limits the success of vaccination protocols based on multiple administrations of the same adenoviral serotype. In this work, we describe efficient immunization of rhesus macaques, the preferred model for preclinical assessment, with an HCV candidate vaccine by heterologous priming-boosting with adenoviral vectors based on different serotypes. The induced responses are broad and show significant cross-strain reactivity. Boosting can be delayed for over 2 years after priming, indicating that there is long-term maintenance of resting memory cells.

机译：有效的针对病毒制剂的疫苗接种需要强大的T细胞介导的免疫反应，以清除被病毒感染的细胞。最佳疫苗接种可以通过施用编码生发素抗原的重组病毒载体来实现。腺病毒载体由于其良好的安全性和肌肉内注射后的有效转导效率，已经成为潜在的用于基因疫苗的病毒载体，引起了广泛的关注。然而，在腺病毒载体注射后针对腺病毒衣壳蛋白的中和抗体应答限制了基于多次给予相同腺病毒血清型的疫苗接种方案的成功。在这项工作中，我们描述了通过基于不同血清型的腺病毒载体的异源引发增强，用HCV候选疫苗有效免疫猕猴（临床前评估的首选模型）。诱导的反应是广泛的，并显示出显着的跨菌株反应性。初次启动后，增强作用可延迟2年以上，这表明可以长期保持静止的记忆细胞。

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E. Fattori; I. Zampaglione; M. Arcuri; A. Meola; B. B. Ercole; A. Cirillo; A. Folgori; A. Bett; M. Cappelletti; E. Sporeno; R. Cortese; A. Nicosia; S. Colloca;
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年度 2006
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正文语种 eng
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1. Efficient immunization of rhesus macaques with an HCV candidate vaccine by heterologous priming-boosting with novel adenoviral vectors based on different serotypes. [J] . Fattori E, Zampaglione I, Arcuri M, Gene therapy . 2006,第14期

机译：通过基于不同血清型的新型腺病毒载体的异源引发增强，用HCV候选疫苗有效免疫恒河猴。
2. Heterologous boosting of recombinant adenoviral prime immunization with a novel vesicular stomatitis virus-vectored tuberculosis vaccine. [J] . Roediger EK, Kugathasan K, Zhang X, Molecular therapy: the journal of the American Society of Gene Therapy . 2008,第6期

机译：异源加强重组腺病毒初免免疫的新型水疱性口炎病毒载体结核病疫苗。
3. Oral immunization of rhesus macaques with adenoviral HIV vaccines using enteric-coated capsules [J] . Mercier GT, Nehete PN, Passeri MF, Vaccine . 2007,第52期

机译：使用肠溶胶囊对腺病毒HIV疫苗进行恒河猴的口服免疫
4. NON-TOXIC ESCHERICHIA C0ULT MUTANTS AND SUPRA-MOLECULAR BIOVECTOR SYSTEM (SMBV~(TM)) FOR INTRANASAL IMMUNIZATION WITH MENINGOCOCCAL CONJUGATED VACCINES [C] . B.C. Baudner, D. Betbeder, O. Balland, International symposium on controlled release of bioactive materials;Consumer diversified products conference . 2001

机译：脑膜炎球菌免疫接种的非毒性大肠埃希氏菌突变和超分子生化系统（SMBV〜（TM））
5. Characterization of viral envelopes and cytokine responses among rhesus macaques immunized with vesicular stomatitis virus-based simian immunodeficiency virus (SIV) vaccines and challenged with pathogenic SIV. [D] . Gambhira, Ratish. 2012

机译：基于水泡性口炎病毒的猿猴免疫缺陷病毒（SIV）疫苗免疫并受到病原性SIV攻击的恒河猴的病毒包膜和细胞因子应答的特征。
6. New Candidate Vaccines against Blood-Stage Plasmodium falciparum Malaria: Prime-Boost Immunization Regimens Incorporating Human and Simian Adenoviral Vectors and Poxviral Vectors Expressing an Optimized Antigen Based on Merozoite Surface Protein 1 [O] . Anna L. Goodman, C. Epp, D. Moss, 2011

机译：针对血液阶段恶性疟原虫疟疾的新候选疫苗：结合人和猿猴腺病毒载体和表达基于裂殖子表面蛋白1优化抗原的痘病毒载体的初免-加强免疫方案
7. New Candidate Vaccines against Blood-Stage Plasmodium falciparum Malaria: Prime-Boost Immunization Regimens Incorporating Human and Simian Adenoviral Vectors and Poxviral Vectors Expressing an Optimized Antigen Based on Merozoite Surface Protein 1, (vol 78, pg 4610, 2010) [O] . Goodman, AL, Epp, C, Moss, D, 2011

机译：针对恶性疟原虫疟疾的新候选疫苗：结合人和猿猴腺病毒载体和表达基于裂殖子表面蛋白1优化抗原的痘病毒载体的初免-加强免疫方案（第78卷，第4610页，2010年）

Efficient immunization of rhesus macaques with an HCV candidate vaccine by heterologous priming-boosting with novel adenoviral vectors based on different serotypes

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